Xue, Fuzhong

Author: Time:2019-06-21 ClickTimes:



Name:Xue Fuzhong

Address:Epidemiology andbiostatistics,school of Public Health, Shandong University, Wenhua Xi Rood, No. 44, Jinan, China


Telephone: +86 0531-88380280

Fax: +86 0531-88380280


Citizenship:Chinese Citizen


I received my PhD inbiostatistics and epidemiology at Department ofepidemiology andbiostatistics,school of Public Health, Shandong University, China; andas Postdoctor inStatistical Genetics and Population Genetics inSchool of Life Science, Fudan University,Shanghai, China.My research focuses on the following areas:

(1) Developingstatisticalmethods ongeneticmapping ofcomplexdiseases, mainly on the gene- or region–based statistical methods forgenome-wide association study. methods for detecting gene-gene interaction and gene-gene co-association.

(2)Spatial genetics of human population, spatial epidemiology. mainly focus onThe spatial epidemiology of tuberculosis,hemorrhagic fever with renal syndrome (HFRS), Hand-foot-mouth disease (HFMD) andHeating with platelet syndrome (HWPS); spatialgenetic structure of human populations and geneticboundariesusing spatial statistics.

(3) Health(or disease)risk appraisal, and statistical pattern recognition in Translational Medicine. The heavy burdens of cardiovascular diseaseand strokewere seen shifting from urban to rural areas in China. Without an assessment tool and method for accurate risk prediction, effective early detection and intervention becomes infeasible. Because Framingham model was designed many years ago in the United States, its limitation in study design, variable selection, and risk calculation makes it not suitable for predicting risks of stroke and other cardiovascular diseases among rural populations of China. Based on theMulticenter cohortand thelarge scalemulticenter longitudinal cohort in Shandong, China,following the principal of suitability and adaptability, we proposed to develop a new strategy of risk prediction using Bayesian hierarchical competing-risk modeling approach. This innovative strategy is able to accommodate data from multiple sources with different epidemiologic study designs (i.e., a multi-center cohort, a case-control study, and a stroke registry). By dividing lifespan into pre-stroke and post-stroke phases, within the framework of Bayesian hierarchical modeling with random-effects in describing the heterogeneity between sub-populations, we developed risk-competing models for predicting the risks of different types of stroke and those of their prognostic outcomes. The method

of Bayesian variable selection will be used in selecting significant predictors from a list of risk factors that are pre-categorized into sub-groups according to their cost and convenience in acquisition and clinical relevance. By developing a set of candidate models, each with distinctive combination of risk factors and baseline risk function estimates, the approach of Bayesian Model Averaging will be applied

to calculate averaged absolute risks, lifespan risks, and relative absolute risks to jointly describe risks of a target individual or community. By adopting this strategy, we aim to study the feasibility of developing the next-generation flexible, adaptable and suitable risk assessment methods and computing tools (instruments and computer software packages) to specifically serve varying needs of different rural populations in China. Accomplishment of this project will offer evidence in developing new methods and tools for effectively and adaptively predicting risks of not only stroke but other chronic diseases in rural area of China.

I have had extensive experience with training and mentoring. I have served as the PI onmany grantsabout geneticmapping ofcomplexdisease,spatial epidemiology and risk assessment of diseases. Through these grants we have successfully trained several young investigators most of whom are currently independently funded. Personally I have trained more than 25postgraduates and PhD trainees and most of whom remain in academic departments.


Sep 1992 - Aug 1996:BSc inpreventive medicine .Department of Epidemiology andbiostatistics,school of Public Health, Shandong University,, Shandong, China

Sep1996 - Aug 1999:Master of Medicine.Department of Epidemiology andbiostatistics,school of Public Health, Shandong University,, Shandong, China

Thesis:Study Onthe spatio-temporal mathematicalmodels ofdisease andtheir Application

Sep 2002- Aug2005:PhD inEpidemiology andBiostatistics.Department of Epidemiology andbiostatistics,school of Public Health, Shandong University, Shandong, China

Thesis:The study of heterogeneity theory and quantitative analysis methodofthe human population spatial genetic structure

Sep 2005– Mar 2008:Postdoctoral training inStatistical Genetics and Population Genetics.Department of human genetics,School of Life Science,Fudan University, Shanghai, China

Thesis: Study on spatial genetic structure of Chinese within GIS framework


Aug 1986– Jul 1996:Section Chiefat Dept. of Epidemiology Section, CDC of Pingyi county, Shandong, China.

Sep 1999- Aug 2004:Lecturer at Dept. of Epidemiology and Statistics, School of Public Health, Shandong University. Shandong, China

Sep 2004-Dec. 2010: Associate Director and Associate Professor at Dept. of Epidemiology and biostatistics, School of Public Health, Shandong University. Shandong, China

Oct. 2009-Nov 2010: Visiting scientist at MRC epidemiology unit, Cambridge University, UK

Oct. 2011-Mar. 2012: Visiting scientist at Division of biostatistics, University of California_Davis, USA

Jan 2008-present:Associate Dean of School of Public Health, Shandong University.Shandong, China

Jan 2010-present: Associate Director and Professor at Dept. of Epidemiology and biostatistics, School of Public Health, Shandong University. Shandong, China


StandingMember,Committee of Medical Statistics Education,Chinese Association of Health Informatics

Member, Committee of Medical Statistics,Theory and Methodology,Chinese Association of Health Informatics

Vice Chair, Committee ofClinical Epidemiology,Shandong Province

Vice Chair,Committee ofHealth Management,Shandong Province


2000“Study On the spatio-temporal mathematical models of disease and their Application” win The Award of “Excellent Master’s Dissertation”.

2005”The study of heterogeneity theory and quantitative analysis method of the human population spatial genetic structure” win The Award of “Excellent Doctor’s Dissertation”.

2009 the Study of spaceepidemiology and its application on the control ofhemorrhagic fever with renal syndrome, win the third division of “science and progress prize ofShandong province”

2010 thetheoretic immune response rate prediction system ofMulti-epitope vaccine design and its control method , gain “the national invention patent”, 2010


(1) 81273177 (PI) ,Develop Appropriate Strategies and Methods for Effectively Predicting Risks of Stroke and Its Prognostic Outcomes among Rural population. 60.00CNY

(2) 31071155 (PI),01/2011– 01/2014 National Natural Science Foundation of China.The statistical inference method research of genome-wide regionalassociation analysis based on the desease phenotype view and latent variables theory. 31.00CNY

(3) 2007AA02Z312 (PI), 06/2007– 07/2010, National “863” Project of China. Study of Gene-gene(Gene-environment) Interaction and Heredity Interaction Network In Gene Mapping of Complex Disease and Exploiture of Corresponding Software System. 113.00CNY

(4) 2007CB512600 (Wang Zhenguo) (Co-l),01/2007– 12/2012, National “973” Project of China. Study of Essential Problems Corresponding To Theory of Chinese Herbal Nature. 50.00CNY

(5)30871392 (PI), 01/2009–01/2012, National Natural Science Foundation of China. Study onstatistical inference methods of interaction between whole genes based on kernel canonical correlationtheory. 30.00CNY

(6) 2005038128 (PI), 2005– 2007, Chinese Postdoctoral Science Fund. Geographic Information System Study of Chinese Population Fine Genetic Structure. 2.00CNY

(7) 30471489 (Wang Jiezhen) (Co-l), 2003– 2006, National Natural Science Foundation of China. Study of Geographical Epidemiological Mechanism of Haemorrhagic Fever with Renal Syndrome In Small Ecological Areas.28.00CNY

(8) 30170527 (PI), 2002– 2005, National Natural Science Foundation of China. Study of Spatial Genetic Heterogeneity Theory and Quantitive Analysis Method. 24.00CNY

(9) 30070677 (Wang Jiezhen) (Co-l), National Natural Science Foundation of China. Study of Statistical Method in Geographical Epidemiology.14.00CNY

(10)30890034, 01/2009– 01/2013, National Natural Science Foundation of China. Genomic polymorphism in Chinese population and related studies of molecular markers,PI Project 3 (30890034-3):China (Han) population genetic structure and its impact on the analysis of complex disease association studies20.00CNY

(11) 2008BAI52B03 (Co-l),09/2008– 09/2011, National Science and Technology Support Program.Study ofearly warning indicatorsofMajor neuropsychiatric disorders and early warning system model development 80.00CNY


[1] Yuan Z, Ji J, Zhang T, Liu Y, Zhang X, Chen W, Xue F*. A novel chi-square statistic for detecting group differences between pathways in systems epidemiology. Stat Med. 2016 Sep 7. doi: 10.1002/sim.7094. [Epub ahead of print]

[2] Li H, Yuan Z, Su P, Wang T, Yu Y, Sun X, Xue F*.A simulation study on matched case-control designs in the perspective of causal diagrams.BMC Med Res Methodol. 2016 Aug 20;16(1):102. doi: 10.1186/s12874-016-0206-3.

[3] Zhang X, Yuan Z, Ji J, Li H, Xue F*. Network or regression-based methods for disease discrimination: a comparison study. BMC Med Res Methodol. 2016 Aug 18;16:100. doi: 10.1186/s12874-016-0207-2.

[4] Zhu Q, Sun X, Ji X, Zhu L, Xu J, Wang C, Zhang C, Xue F, Liu Y.The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.Sci Rep. 2016 Jul 22;6:29937. doi: 10.1038/srep29937.

[5] Zhang T, Zhang H, Li Y, Sun D, Li S, Fernandez C, Qi L, Harville E, Bazzano L, He J,Xue F, Chen W.Temporal Relationship Between Childhood Body Mass Index and Insulin and Its Impact on Adult Hypertension: The Bogalusa Heart Study.Hypertension. 2016 Sep;68(3):818-23. doi: 10.1161/HYPERTENSIONAHA.116.07991. Epub 2016 Jul 18.

[6] Li J, Xu X, Ding G, Zhao Y, Zhao R, Xue F, Li J, Gao J, Yang J, Jiang B, Liu Q.A Cross-Sectional Study of Heat Wave-Related Knowledge, Attitude, and Practice among the Public in the Licheng District of Jinan City, China.Int J Environ Res Public Health.2016 Jun 29;13(7). pii: E648. doi: 10.3390/ijerph13070648.

[7] Li R, Lin H, Liang Y, Zhang T, Luo C, Jiang Z, Xu Q, Xue F, Liu Y, Li X. The short-term association between meteorological factors and mumps in Jining, China.Sci Total Environ. 2016 Oct 15;568:1069-75. doi: 10.1016/j.scitotenv.2016.06.158. Epub 2016 Jun 25.

[8]Wang S, Zhang C, Zhang G, Yuan Z, Liu Y, Ding L, Sun X, Jia H, Xue F.Association between white blood cell count and non-alcoholic fatty liver disease in urban Han Chinese: a prospective cohort study.BMJ Open. 2016 Jun 1;6(6): e010342. doi:10. 1136/bmjopen-2015-010342.

[9] Li H,Yuan Z,Ji J,Xu J,Zhang T,Zhang X,Xue F*.A novel Markov Blanket-based repeated-fishing strategy for capturing phenotype-related biomarkers in big omics data.BMC Genet. 2016 Mar 9;17(1):51. doi: 10.1186/s12863-016-0358-5.

[10] Zhu L, Wang X, Guo Y, Xu J, Xue F, Liu Y.Assessment of temperature effect on childhood hand, foot and mouth disease incidence (0-5years) and associated effect modifiers: A 17 cities study in Shandong Province, China, 2007-2012.Sci Total Environ. 2016 Feb 15;551-552:452-459. doi: 10.1016/j.scitotenv.2016.01.173.

[11] Ji J, Yuan Z, Zhang X,Xue F*.A powerful score-based statistical test for group difference in weighted biological networks.BMC Bioinformatics. 2016 Feb 12;17(1):86.doi:10.1186/s12859-016-0916-x.

[12] Xu J, Li L, Wei L, Nie Z, Yang S, Xia M, Ma T, Sun H, Zhao X, Ping Y, Zhou H, Xue F, Zhao Z, Jin L, Li S Genetic analysis of 17 Y-STR loci in Han population from Shandong Province in East China.Forensic Sci Int Genet. 2016 Jan 28. pii: S1872-4973(16)30016-3. doi: 10.1016/j.fsigen.2016.01.016.

[13] Xu J, Yuan Z, Ji J, Zhang X, Li H, Wu X, Xue F, Liu Y.A powerful score-based test statistic for detecting gene-gene co-association.BMC Genet. 2016 Jan 29;17(1):31. doi: 10.1186/s12863-016-0331-3.

[14] Zhang T, Du J, Yin X, Xue F, Liu Y, Li R, Luo C, Li L, Li X.Adverse Events in Treating Smear-Positive Tuberculosis Patients in China.Int J Environ Res Public Health. 2015 Dec 29;13(1). pii: E86. doi: 10.3390/ijerph13010086.

[15] Gao N,Yuan Z,Tang X,Zhou X,Zhao M,Liu L,Ji J,Xue F,Ning G,Zhao J, Zhang H,Gao L.Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study.J Diabetes Complications. 2015 Nov 24.pii:S1056-8727(15)00456-0.doi: 10.1016/j.jdiacomp.

[16] Ding L, Zhang C, Zhang G, Zhang T, Zhao M, Ji X, Yuan Z, Liu R, Tang F, Xue F*.A new insight into the role of plasma fibrinogen in the development of metabolic syndrome from a prospective cohort study in urban Han Chinese population.Diabetol Metab Syndr. 2015 Dec 2;7:110. eCollection 2015.

[17] Zhang W,Wang L,Chen Y,Tang F,Xue F,Zhang C Identification of Hypertension Predictors and Application to Hypertension Prediction in an Urban Han Chinese Population: A Longitudinal Study, 2005-2010.Prev Chronic Dis.2015 Oct 29;12:E184. doi:10.5888/pcd12. 150192

[18] Zhang Y, Zhang T, Zhang C, Tang F, Zhong N, Li H, Song X, Lin H, Liu Y, Xue F*Identification of reciprocal causality between non-alcoholic fatty liver disease and metabolic syndrome by a simplified Bayesian network in a Chinese population.BMJ Open.2015 Sep 22;5(9):e008204.doi:10.1136/bmjopen-2015-008204.

[19] Song G, Xue F, Zhang C A Model Using Texture Features to Differentiate the Nature of Thyroid Nodules on Sonography.J Ultrasound Med. 2015 Aug 25. pii: 15.14.10045.

[20] Tang F, Xue F,Qin P The interplay of stressful life events and coping skills on risk for suicidal behavior among youth students in contemporary China: a large scale cross-sectional study.BMC Psychiatry. 2015 Jul 31;15:182.

[21] Zhu L, Yuan Z, Wang X, Li J, Wang L, Liu Y, Xue F, Liu Y The Impact of Ambient Temperature on Childhood HFMD Incidence in Inland and Coastal Area: A Two-City Study in Shandong Province, China.Int J Environ Res Public Health. 2015 Jul 23;12(8):8691-704.doi: 10.3390/ijerph120808691.

[22] Yuan Z, Zhao M, Zhang B, Zhang H, Zhang X, Guan Q, Ning G, Gao L, Xue F, Zhao J Thyroid function modifies the association between ratio of triglyceride to high-density lipoprotein cholesterol and renal function: a multicenter cross-sectional study.Sci Rep.2015 Jul 16;5:11052.doi: 10.1038/srep11052.

[23] Li J, Liu R, Ji X, Xue H,Zhang G, Wang C, Chen Q, Xue F, Cui L Insight into the Spectrum of Coronary Atherosclerosis in Asymptomatic Urban Han Chinese Population by Coronary Computed Tomography Angiography.PLoS One.2015 Jul 7;10(7):e0132188. doi: 10.1371/journal.pone.0132188. eCollection 2015.

[24] Tian T, Yu S, Liu L, Xue F, Yuan C, Wang M, Ji C, Ma D.The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations.PLoS One. 2015 Jul 2;10(7):e0131761.doi:10.1371/journal.

[25] Liu YX, Pang C, Liu Y, Sun XB, Li XX, Jiang SW, Xue F*. Association between Multidrug-resistant Tuberculosis and Risk Factors in China: Applying Partial Least Squares Path Modeling. PLoS One. 2015,10(5):e0128298.

[26] Liu Y, Wang X, Pang C, Yuan Z, Li H, Xue F* Spatio-temporal analysis of the relationship between climate and hand, foot, and mouth disease in Shandong province, China, 2008-2012.BMC Infect Dis. 2015 Mar 24;15(1):146. doi: 10.1186/s12879-015-0901-4.

[27] Zhang T, Zhang C, Zhang Y, Tang F, Li H, Zhang Q, Lin H, Wu S, Liu Y, Xue F*.Metabolic syndrome and its components as predictors of nonalcoholic fatty liver disease in a northern urban Han Chinese population: A prospective cohort study.Atherosclerosis. 2015 Mar 11;240(1):144-148.

[28] Zhao M, Yang T, Chen L, Tang X, Guan Q, Zhang B, Zhang X, Zhang H, Wang C, Xu J, Hou X, Li Q, Yu C, Zhao Y, Fang L, Yuan Z, Xue F, Ning G, Gao L, Xu C, Zhao J.Subclinical Hypothyroidism Might Worsen the Effects of Aging on Serum Lipid Profiles, a Population-based Case-control Study.Thyroid. 2015 Mar 17.

[29] Wang H, Du Z, Wang X, Liu Y, Yuan Z, Liu Y,Xue F*.Detecting the association between meteorological factors and hand, foot, and mouth disease using spatial panel data models.Int J Infect Dis. 2015 Mar 11. pii: S1201-9712(15)00068-5. doi: 10.1016/j.ijid.2015.03.007.

[30] Zhao M, Tang X, Yang T, Zhang B, Guan Q, Shao S, Xue F, Zhang X, Liu Z, Yuan Z, Song Y, Zhang H, Fang L, Yu C, Li Q, Zhang X, Gao L, Xu C, Zhao J. Lipotoxicity,a Potential Risk Factor for The Increasing Prevalence of Subclinical Hypothyroidism? J Clin Endocrinol Metab. 2015 Mar 5:jc20143987.

[31] Zhang W, Chen Q, Yuan Z, Liu J, Du Z, Tang F, Jia H, Xue F, Zhang C. A routine biomarker-based risk prediction model for metabolic syndrome in urban Han Chinese population.BMC Public Health. 2015 Jan 31;15(1):64.

[32] Wang S, Liu Y, Li F, Jia H, Liu L, Xue F*. A novel quantitative body shape score for detecting association between obesity and hypertension in China. BMC Public Health.2015 Jan 17;15(1):7.

[33] Ji J, Yuan Z, Zhang X, Li F, Xu J, Liu Y, Li H, Wang J, Xue F*. Detection for pathway effect contributing to disease in systems epidemiology with a case-control design.BMJ Open. 2015 Jan 16;5(1):e006721. doi: 10.1136/bmjopen-2014-00672

[34] Liu J, Lin H, Zhang C, Wang L, Wu S, Zhang D, Tang F, Xue F, Liu Y. Non-alcoholic fatty liver disease associated with gallstones in females rather than males:a longitudinal cohort study in Chinese urban population.BMC Gastroenterol.2014 Dec 13;14(1):213.

[35] Wang SK, Ma W, Wang S, Yi XR, Jia HY, Xue F*. Obesity and Its Relationship with Hypertension among Adults 50 Years and Older in Jinan, China. PLoS One.2014 Dec 17;9 (12):e114424.

[36] Zhang X, Xue F, Liu H, Zhu D, Peng B, Wiemels JL, Yang X. Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies.BMC Genet.2014 Dec 10;15(1):130.

[37] Yuan Z,Zhang X, Li F, Zhao J,Xue F*.Comparing partial least square approaches in a gene-or region-based association study for multiple quantitative phenotypes.Hum Biol.2014 Feb;86(1):51-8

[38] Zhao M, Liu F, Liu W, Ji X, Xue F* Health management in China. Int J Cardiol. 2014.176(1): 234.

[39] Du Z,Wang Z,Liu Y,Wang H,Xue F,Liu Y.Ecological niche modeling for predicting the potential risk areas of severe fever with thrombocytopenia syndrome. Int J Infect Dis.2014.26C:1-8.

[40] Zhang T,Zhang Y,Zhang C,Tang F, Li H,Zhang Q, Lin H, Wu S, Liu Y,Xue F*Prediction of metabolic syndrome by non-alcoholic fatty liver disease in northern urban Han Chinese population: a prospective cohort study.PLoS One.2014. 9(5):e96651.

[41] Wu S,Lin H, Zhang C,Zhang Q,Zhang D,Zhang Y,Meng W,Zhu Z,Tang F,Xue F,Liu Y.Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.BMC Public Health.2013.13:989.

[42] Zhu Z, Liu Y, Zhang C,Yuan Z,Zhang Q,Tang F,Lin H,Zhang Y,Liu L,Xue F*.Identification of cardiovascular risk components in urban Chinese with metabolic syndrome and application to coronary heart disease prediction: a longitudinal study. PLoS One.2013 Dec 17;8(12):e84204.

[43] Li F,Zhao J,Yuan Z,Zhang X,Ji J,Xue F*.A powerful latent variable method for detecting and characterizing gene-based gene-gene interaction on multiple quantitative traits.BMC Genet.2013 Sep 23;14:89.

[44] Yuan Z,Liu H,Zhang X,Li F,Zhao J,Zhang F,Xue F*. From interaction to co-association--a Fisher r-to-z transformation-based simple statistic for real world genome-wide association study.PLoS One.2013 Jul 29;8(7):e70774.

[45] Liu L,Xue F,Ma J,Ma M,Long Y,Newschaffer CJ.Social position and chronic conditions across the life span and risk of stroke: a life course epidemiological analysis of22847 American adults in ages over 50.Int J Stroke.2013 Oct;8 Suppl A100:50-5.

[46] Zhang X,Yang X,Yuan Z,Liu Y,Li F,Peng B,Zhu D,Zhao J,Xue F*.A PLSPM-Based Test Statistic for Detecting Gene-Gene Co-Association in Genome-Wide Association Study with Case-Control Design.PLoS One.2013 Apr 19;8(4):e62129.

[47] Yuan Z, Gao Q, He Y,Zhang X,Li F,Zhao J,Xue F*.Detection for gene-gene co-association via kernel canonical correlation analysis.BMC Genet.2012 Oct 8;13(1):83.

[48] Xue F*, Li S, Luan J, Yuan Z, Luben RN, Khaw KT, Wareham NJ, Loos RJ, Zhao JH*. A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. PLoS One.2012;7(2):e31927

[49] Li M,Heng X,Tao R,Liu J,Zhang L,Sun X,Wang L,Wu Q,Che F*,Xue F* .A genetic epidemiological survey of idiopathic epilepsy in the Chinese Han population.Epilepsy Res.2012;98(2-3):199-205.

[50] Zhang Q, Zhang C, Song X, Lin H, Zhang D, Meng W, Zhang Y,Zhu Z, Tang F, Liu L,Yang X, Xue F*. A longitudinal cohort based association study between uric acid leveland metabolic syndrome in Chinese Han urban male population. BMC Public Health.2012 Jun 8;12:419.

[51] Li X,Sun X,Jin L,Xue F*. Worldwide spatial genetic structure of angiotensin-converting enzyme gene: a new evolutionary ecological evidence for the thrifty genotypehypothesis.Eur J Hum Genet.2011;19(9):1002-1008.

[52] Gao Q,He Y,Yuan Z,Zhao J,Zhang B, Xue F*.Gene-or region-based association study via kernel principal component analysis.BMC Genet.2011 Aug 26;12:75.

[53] Peng Q,Zhao J,Xue F*.A gene-based method for detecting gene-gene co-association in a case-control association study.Eur J Hum Genet.2010;18(5):582-587.

[54] Peng Q,Zhao J*,Xue F*.PCA-based bootstrap confidence interval tests for gene-disease association involving multiple SNPs.BMC Genet. 2010 Jan 26;11:6.

[55] Zheng Q, Shi Y, Yang Z, Xu X, Wang L, Xue F, Gu HF, Chen ZJ*. Family-based association study of the MCF2L2 gene and polycystic ovary syndrome. Gynecol ObstetInvest.2009;68(3):171-173.

[56] Xue F*,Wang Y,Xu S,Zhang F,Wen B,Wu X,Lu M,Deka R,Qian J,Jin L*.A spatial analysis of genetic structure of human populations in China reveals distinct difference betweenmaternal and paternal lineages.Eur J Hum Genet.2008;16(6):705-717.

[57] Zhao P,Ma DX,Yu S,Xue FZ,Zhu WW,Shao N,Zhang JR,Ji CY.The development of Chinese specific human cytomegalovirus polyepitope recombinant vaccine.Antiviral Res.2012 Feb; 93(2):260-9.

[58] Liu Y, Jiang S, Liu Y, Wang R, Li X, Yuan Z, Wang L, Xue F*. Spatial epidemiology and spatial ecology study of worldwide drug-resistant tuberculosis. Int J HealthGeogr. 2011Aug3;10:50.

[59] Sun L, Shao Q, Wang ZQ, Kang DM, Li SW, Li XG, Xue FZ, Wang JZ. Spatial structure of rodent populations and infection patterns of hantavirus in seven villages of ShandongProvince from February 2006 to January 2007.Chin Med J (Engl).2011 Jun;124(11):1639-46.

[60] Xue F*, Wang J, Hu P,Ma D,Liu J,Li G,Zhang L,Wu M,Sun G,Hou H. Identification of spatial genetic boundaries using a multifractal model in human population genetics.HumBiol.2005;77(5):577-617

[61] Xue F*,Wang J,Ma D,Li G,Hu P.Spatial genetic structure of two HIV-I-resistant polymorphisms (CCR2-64 I and SDF1-3'A) alleles in population of Shandong Province,China.BiomedEnviron Sci. Aug 2005(18):241-253

[62] Xue F*, Wang J,Hu P,Li G.The “Kriging” model of spatial genetic structure in human population genetics.Yi Chuan Xue Bao.Mar 2005(32):219-233

School of Public Health, Shandong University   44 West Wenhua Road, Jinan, Shandong Province, 250012, China