Curriculum Vitae
Basic Information
Name: Zhihui Feng,
Title: MD, Ph.D, Professor, Supervisor for Ph.D, MPH and master degree, the director of the Department of Occupational and Environmental Health,
Email: fengzhihui@sdu.edu.cn
Tel: 13573146295
Academic Experience
1982-1987: MD, Harbin Medical University
1987-1990: MPH, Harbin Medical University
1995-1998: Ph.D, Peking University School of Basic Medical Science
Working Experience
1990-1995: Qiqihar Medical University, instructor, assistant professor, director of the department
1998-2001: Peking University School of Basic Medical Science, assistant professor, associate professor, vice director of the department
2001-2009: Department of Radiation Oncology, Harvard Medical School Massachusetts General Hospital and Washington University in St Louis
2010-present: Public Health School in Shandong University, professor, supervisor for MPH, the vice director of the department
Research Interests
Dr Feng’s research work has focused on understanding the molecular mechanisms that regulate the repair of DNA breaks induced by ionizing radiation; and understanding how disruption of DNA repair pathway sensitizes the tumor cells to radiation and chemotherapeutic drugs. Some research results were published in PNAS, Nucleic Acid Research, DNA repair, J Biological Chemistry, Toxicology Research, etc; and cooperation work was published in Nature, J. Cell Biology, Cancer Research, etc.
Dr Feng’s research interests include DNA damage and repair, the mechanism of breast cancer induced by carcinogens, radiotherapy and chemotherapy to tumor cells, the effect of low dose radiation on radiation workers, as well as the relationship between occupational hazards and genetic stability.
Research Funds
2010--Independent Innovation Foundation of Shandong University in China (2010TB017), 2010.10-2012.12, Principle Investigator
2012--National Natural Science Foundation of China (81172527), 2011.1-2015.12, Principle Investigator
2013--Science and Technology Department of Shandong Province in China (2013GGE27052), 2013.1-2015.12, Principle Investigator
2015--National Natural Science Foundation of China (81472800), 2015.1-2018.12, Principle Investigator
2015--Science and Technology Department of Shandong Province in China (2014GGH218010), 2015.1-2017.12, Principle Investigator
Main Publications
Youjia Tian, Guochao Liu, Hui Wang, Zhujun Tian, Zuchao Cai, Fengmei Zhang, Yue Luo, Shue Wang, Gongshe Guo, Xiaowei Wang, Simon Powell, Zhihui Feng (corresponding author); Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway; DNA repair, accepted in 2017(IF 3.455)
Guochao Liu, Hui Wang, Fengmei Zhang, Youjia Tian, Zhujun Tian, Zuchao Cai, David Lim and Zhihui Feng (corresponding author), The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats, Int. J. Mol. Sci. 2017, 18, 1027; doi:10.3390/ijms18051027 (IF 3.482)
Hui Wang, Qianshu Chen, Guochao Liu, Youjia Tian, Fengmei Zhang, Jianying Qu, David Lim and Zhihui Feng (corresponding author) The comparison of health status between male and female medical radiation workers in china, Radiation Protection Dosimetry, 2017, Jan 16. doi: 10.1093/rpd/ncw380.
*Y Luo, H Wang, X Zhano, C Dong, F Zhang, G Guo, G Guo, X Wang, S N. Powell and Zhihui Feng (corresponding author) , valproic acid causes radiosensitivity to breast cancer cells via inhibiting DNA repair pathway, Toxicol. Res., 2016, 5, 859–870 (IF3.983)
*Dong C, Zhang F, Luo Y, Wang H, Zhao X, Guo G, Powell SN, Feng Zhihui (corresponding author), p53 suppresses hyper-recombination by modulating BRCA1 function, DNA repair, 2015 Sep;33:60-9 (IF 3.455)
*Guo GS, Zhang FM, Gao RJ, Delsite R, Feng ZhiHui*, Powell SN. DNA repair and synthetic lethality. Int J Oral Sci. 2011 Oct; 3 (4):176-9 (IF 2.719, corresponding author, invited review)
*Zhihui Feng, Junran Zhang, A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest; Nucleic Acids Res. 2012 Jan 40(2):726-38 (IF 9.112)
*Zhihui Feng, Shaun P. Scott, Wendy Bussen, Girdhar G. Sharma, Gongshe Guo, Tej K. Pandita,Simon N. Powell; Rad52 inactivation is Synthetically Lethal with BRCA2-deficiency. Proc Natl Acad Sci U S A. 2011 Jan 11; 108 (2):686-91. (IF 9.809)
*Beth A. Helmink, Anthony Tubbs, Yair Dorsett, Jeffrey J. Bednarski, Laura M. Walker, Zhihui Feng, Girdhar Sharma, Richard Baer, Peter J. McKinnon, Junran Zhang, Craig H. Bassing and Barry P. Sleckman, H2AX Inhibits CtIP-Mediated DNA End Resection and Aberrant Homology-Mediated Repair in G1-Phase Cells. Nature. 2011 Jan 13;469(7329):245-9. Epub 2010 Dec 15 (IF 36.101)
*Zhihui Feng, W Shi, J Zhang, I Gonzalez-Suarez, X Wu, S. N. Powell, S Gonzalo and J Zhang; The Role of RPA2 Phosphorylation in Homologous Recombination in Response to Replication Arrest, Carcinogenesis. 2010 Jun;31(6):994-1002. Epub 2010 Feb 3(#co-first author, IF 5.402)
*Y Wang, O Deng, Zhihui Feng, Z Du, X Xiong, J Lai, X Yang, M Xu, H Wang, D Taylor, C Yan, C Chen, A Difeo, and Z Ma, J Zhang, RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression, Oncogene, 2015 Aug 3. doi: 10.1038/onc.2015.198. [Epub ahead of print] (IF8.459)
*Xiong X, Du Z, Wang Y, Feng Zhihui, Fan P, Yan C, Willers H, Zhang J，53BP1 promotes microhomology-mediated end-joining in G1-phase cell, Nucleic Acids Res. 2015 Feb 18; 43 (3) (IF 9.112)
*Grotsky DA, Gonzalez-SuarezI, Novell A, Neumann MA, Yaddanapudi SC, Croke M, Martinez-Alonso M, Redwood AB, Ortega-Martinez S, Feng Zhihui, Lerma E, Ramon T, Zhang J, Matias-Guiu X, Dusso A, Gonzalo S. BRCA1 loss activities cathepsin L-mediated degradation of 53BP1 in breast cancer cells. J Cell Biol. 2013 Jan 21; 200 (2):187-202 (IF 9.688)
*Abena Redwood, Stephanie Perkins, Robert Vanderwaal, Zhihui Feng, Kenneth Biehl, Ignacio Gonzalez-Suarez, Lucia Morgado-Palacin, Wei Shi, Joseph Roti-Roti, Colin Stewart, Junran Zhang, Susana Gonzalo; A dual role for A-type lamins in DNA double-strand breaks repair, Cell Cycle. 2011 Aug 1; 10 (15). [Epub ahead of print] (IF 4.999)
*Chen H, Ma Z, Vanderwaal RP, Feng Zhihui, Gonzalez-Suarez I, Wang S, Zhang J, Roti Roti JL, Gonzalo S, Zhang J. The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair. Radiat Res. 2011 Feb;175 (2):214-24. Epub 2010 Oct 26 (IF 2.578)
*Zhihui Feng, L Kachnic, J Zhang, SN Powell and F Xia, DNA damage induces p53-dependent BRCA1 nuclear export, JBC. 2004 Jul 2;279 (27):28574-84 (IF 5.328)
*郭刚，王慧，陈倩姝，刘国超，凤志慧，医务放射人员心血管健康异常的影响因素研究, 中国辐射卫生，2016年第06期671-675页.
*王慧，张凤梅，凤志慧（通讯作者），修复DNA双键断裂损伤的NHEJ分子机制研究进展，毒理学杂志，2015年第29卷第6期468-72页.
*罗月，郭刚，董超，赵锡鹏，张凤梅，凤志慧（通讯作者），DNA损伤制剂对携带BRCA1功能位点突变细胞的毒性作用研究，环境与健康杂志，2015年第32卷第5期384-388页
*韩文涛，罗月，凤志慧（通讯作者），组蛋白去乙酰化酶抑制剂与DNA损伤修复机制之间关系的研究进展，中国毒理学和药理学杂志，2015年第29卷第4期633-637页。
*陈倩姝，凤志慧（通讯作者），张有忠，李敏，德州市医用诊断X射线机防护现状调查分析，中国辐射卫生，2015年第01期13-16页
*赵锡鹏，罗月，董超，张凤梅，凤志慧（通讯作者），丙戊酸对乳腺肿瘤细胞的放射敏感性影响的研究，中国药理学与毒理学，2015年02期247-252页
*郭兰田，马珍珍，冯艳，凤志慧（通讯作者），MSCT 在甲状腺良恶性结节诊断中的价值，滨州医学院学报，2015年第4期30-32页
*董超，张凤梅，赵锡鹏，郭公社，罗月，凤志慧（通讯作者），乳腺癌细胞系HCC1937和MCF7在DNA损伤修复反应时功能的比较，中华预防医学杂志，2014年48卷第9期809-814页
*赵锡鹏，张凤梅，凤志慧（通讯作者），乳腺癌易感基因1在DNA损伤修复中的作用研究进展，中国毒理学与药理学杂志，2014年第28期第3卷3-10页
Oral Presentation in International and National Conferences
2016—The 26th Chin-Kore-Japan Joint Conference on Occupational Health, Invited speaker, Beijing 05，19-21.
2015--中国毒理学会第七次全国毒理学大会，表观遗传学分会场主持人和受邀报告，武汉，中国，10，25-28.
2014--4th Asian Conference of Environmental Mutagens”, Invited speaker, Kolkata, India, 12-9-13.
2014--中国环境诱变剂学会第十六次学术大会，青年论坛会场主持人，南京，中国，11月6-8日.
2014--the 5th International Conference on Frontiers in Biomedical and Environmental Health, icBEST-2014; The 5th International Symposium on DNA Damage Response & Human Disease (isDDRHD-2014), Invited speaker, 10/16-19/2014, Beijing, China.
2014--第十次中国毒理学会放射毒理专业委员会全国学术会议，暨第九届全军辐射医学专业委员会第二次学术大会，受邀报告，8 月 27-29日，青岛，中国。
2013--the 14th international Conference on combined Actions and Combined Effects of Environmental Factors (ICCEF), Invited speaker, 10-“13-16”-2013, Wuhan, China.
2012--3rd Asia conference of environmental mutagens (3rd ACEM), Invited speaker, 10-23-2012, Hangzhou, china.
Academic Adjunct Working
*The Active Member of Council of Chinese Environmental Mutagen Society
*The Active Member of the Committee of Radiation Toxicology of Chinese Society of Toxicology
*Reviewer for National Natural Science Foundation of China, NSF of Shandong and Zhejiang Provence
*“Toxicology Research” reviewer, “Cancer Science” editorial board
