CURRICULUM VITAE of ZHAO XIULAN

Department of Toxicology and Nutrition

School of Public Health

Shandong University

#44 Wenhua Xi Road

Jinan, Shandong Province 250012

P.R. China.

E-mail address: zhao.xl@sdu.edu.cn

 

Education

2002/9-2005/7  Ph.D. (Physiology/Neurotoxicology)

School of Medicine, Shandong University, Jinan, China

Dissertation: mechanisms of organophosphorus ester induced delayed neurotoxicity in hens. Advisor: Xie keqin M.D, Ph.D.

 

1995/9-1998/7 Master of nutrition & medical statistics,

School of Public Health, Shandong University, Jinan, China

Thesis: study on the inhibition of human breast cancer cell line BCaP-37 by flavonoids extract of wheat germ and its molecular mechanisms. Advisor: Wang Jiezhen M.D and Xu guifa M.D, Ph.D.

 

1979/9-1984/7 BA in Preventive Medicine

Shandong Medical University, Jinan, Shandong, China.

 

Training

2007/10-2008/11  Visiting Scholar. Comprehensive Cancer Center, The Ohio State University

2001/4 -2001/7  Participant. University of the Philippines Los Banos, Laguna, Phillipines. Seventh short-term course on food and nutrition program planning and management

1982/9 – 1983/2    Resident (Clinical Medicine).The Third Hospital of Jinan, Jinan, China.

 

Professional Experience

2007/10-present Professor. Dean of Department of Toxicology and Nutrition, Shandong University.

2004/9 -2017/10  Professor, Dean of Institute of Toxicology, Shandong University.

2000/1- 2004/8.  Associate Professor. Institute of nutrition and  food hygiene,

Shandong University

1992/1- 1995/9; 1998/7- 1999/12. Lecturer. Institute of Nutrition and Food Hygiene, Shandong University.

 

Research Exerience

1. The roles of microglia M1 polarization and released exosome in the neurotoxicity induced by 1-bromopropane. It funded by National Natural Science Foundation (81872654). 2019/01-2022/12. In charge.

2. The unbalance of microglia M1 polarization and the neurotoxicity of 1-bromopropane based on the ASK1-JNK/p38MAPK signal pathway. It funded by Natural Science Foundation of Shandong Province (ZR2017MH002 ). 2017/08-2020/06. In charge.

3. The roles of environmental neurotoxin in the the occurrence and development of Alzheimer's disease. It funded by Shandong University interdisciplinary cultivation project (2016JC020).

4. Mechanisms of peripheral neurotoxicity induced by 1-bromopropane neurotoxicity of 1-bromopropane. It funded by National Natural Science Foundation (81172708). 2012/01-2015/12. In charge.

5. The damages of new neurotoxin on the professional workers exposed to it and its mechanisms. It funded by National Scientific Key Project of Shandong province (2011GSF11814). 2011/12-2012/12. In charge.

6. Mitochondrial dysfunction and delayed neurotoxicity. It funded by Shandong Province Natural Science Foundation (Y2007C019). 2008/01-2010/12. In charge.

7. Mechanisms of damage caused by environmental chemical pollutants. It supported by grants from National Basic Research Program by Ministry of Science and Technology of China (2002CB512907). 2002/01-2008/12. Major participant.

8. Key technology of treatment of acute poisoning and delayed neurotoxicity caused by organophosphate. It supported by grants from the key program of Science and Technology of Shandong Province (2005GGC03151). 2006/01-2008/01. Major participant.

9. Apo-AⅣ serum levels & it’s influence factors of Chinese. It funded by The National Natural Science Foundation of China (30371211). 2001/01-2003/12. Participant.

10. Protection of dietary polyphenols on endothelial cells under oxidative stress. It funded by Shandong Province Natural Science Foundation (Y2002C42). 2002/01-2005/12. 50 thousand-yuan. In charge.

11. Key technology of diagnosis and treatment of acute poisoning caused by phosphate pesticides and it’s long term negative effect on human body. It supported by grants from the 10^th five year plan of Ministry of Science and Technology of China(2001BA704B06). 2002/01-2004/04. Major participant.

12. Study on mutation of Leptin and its receptor of Chinese. It funded by the National Natural Science Foundation of China (NSFC) (30170803). 2001/01-2003/12. Participant.

13. Study on repressive mechanism of dadezin on the breast cancer. It funded by Shandong Province Natural Science Foundation(1999B24). 1999/01-2002/12. In charge.

 

Major Publications

1.        Xu L, Qiu X, Wang S, Wang Q, Zhao XL*. NMDA receptor antagonist MK-801 protects against 1-BP-induced cognitive dysfunction. Neurosci Bull.  2019 Apr;35(2):347-361.

2.        Suo J, Zhang C, Wang P, Hou L, Wang Q,  Zhao X*. Allyl sulfide counteracts 1-bromopropane-induced neurotoxicity by inhibiting neuroinflammation and oxidative stress. Toxicol Sci.  2019 Feb 1;167(2):397-407

3.        Suo J, Zhao X, Guo X, Zhao X*. Met-enkephalin improves metabolic syndrome in high fat diet challenged mice throughpromotion of adipose tissue browning. Toxicol Appl Pharmacol. 2018 Sep 14;359:12-23.

4.        Xu L, Zhang W, Liu X, Zhang C, Wang P, Zhao X*. Circulatory Levels of Toxic Metals (Aluminum, Cadmium, Mercury, Lead) in Patients with Alzheimer's Disease: A Quantitative Meta-Analysis and Systematic Review. J Alzheimers Dis. 2018;62(1):361-372. doi: 10.3233/JAD-170811.

5.        Wang Z, Wei X, Yang J, Suo J, Chen J, Liu X, Zhao X*. Chronic exposure to aluminum and risk of Alzheimer's disease: A meta-analysis. Neurosci Lett. 2016 Jan 1;610:200-6. doi: 10.1016/j.neulet.2015.11.014. Epub 2015 Nov 27.

 

Teaching Experience

2002/7-present

Toxicology (4th year undergraduate), Biochemical Toxicology (graduate),

Immunohistochemistry and EnzymeHistochemistry (graduate)

 

1984/7- 2002/6

Nutrition and Food Hygiene (4th year undergraduate),

Clinical Nutrition (3rd year undergraduate).

(Institute of Nutrition and Food Hygiene, Shandong University, Jinan, China)