Curriculum Vitae
NAME: Tao Zeng, MD.
OFFICE ADDRESS: Institute of Toxicology, School of Public Health, Shandong University
44 West Wenhua Road, Jinan City, Shandong Province 250012
E-mail: zengtao@sdu.edu.cn
Tel: 86-0531-88382132
Fax:86-0531-88382532
EDUCATION: 09/2005 – 06/2010 M.D., Shandong University
09/2000 – 06/2005 B. Sc., Shandong University
MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS
Society for Free Radical Research (SFRR)-Europe
Chinese Society of Toxicology (CST)
Shandong Preventive Medicine Association (SPMA)
Shandong Laboratory Animal Science Association (SLASA)
RESEARCH INTERESTS
My current research focuses on exploring the underlying mechanisms for the deleterious effects of some chemicals (especially industrial toxicants and environmental contaminants) on the liver and evaluating the hepatoprotective effects of natural compounds against chemicals-induced liver injury.
PROFESSIONAL WORKING AND TEACHING EXPERIENCE
09/2014 – present Associate Professor in School of Public Health, Shandong University, China
Teaching “Toxicology” and “Mechanistic toxicology” for graduate students and “Food toxicology”
and “Experiments of toxicology” for undergraduate students
07/2010 - 08/2014 Lecture in School of Public Health, Shandong University, China
Teaching “Food toxicology” and “Experiments of toxicology” for undergraduate students
PUBLICATIONS
ARTICLES
1. Zeng T, Zhang CL, Zhao N, Guan MJ, Xiao M, Yang R, Zhao XL, Yu LH, Zhu ZP, Xie KQ. Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. Redox Biology, 2018, 14:295-304
2. Zhao YY, Yang R, Xiao M, Guan MJ, Zhao N and Zeng T, Kupffer cells activation promoted binge drinking-induced fatty liver by activating lipolysis in white adipose tissues. Toxicology, 2017, 390:53-60.
3. Zeng T, Zhang CL, Xiao M, Yang R, Xie KQ, Critical roles of Kupffer cells in the pathogenesis of alcoholic liver disease: from basic science to clinical trials. Frontiers in Immunology, 2016, 7: 538.
4. Wang Y, Zhao YY, Li MZ, Yu SQ, Zeng T. Docosahexaenoic acid supplementation failed to attenuate chronic alcoholic fatty liver in mice. Acta Biochim Biophys Sin, 2016, 48, 482-484.
5. Zeng T, Zhao YY, Xie, KQ. Does Intestinal Microbiota Protect Mice Against Acute/Binge Drinking-Induced Liver Injury? Alcohol Clin Exp Res, 2016, 40, 1788-1790.
6. Zhao YY, Xiao M, Zhang CL, Xie KQ, Zeng, T. Associations between the tumor necrosis factor-alpha gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease: A meta-analysis. Clin Res Hepatol Gastroenterol, 2016, 40, 428-439.
7. Chen YY, Zhang CL, Zhao XL, Xie KQ, Zeng T. Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. Chem Biol Interact. 2014, 222C:18-26.
8. Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ.CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway. PLoS One. 2014, 9(6):e98658.
9. Zeng T, Zhang CL, Zhao XL, Xie KQ. Pentoxifylline for the treatment of nonalcoholic fatty liver disease: a meta-analysis of randomized double-blind, placebo-controlled studies. Eur J Gastroenterol Hepatol. 2014, 26(6):646-53.
10. Yin HY, Guo Y, Song FY, Zeng T, Xie KQ. Toxicokinetic study of pyrrole adducts and its potential application for biological monitoring of 2,5-hexanedione subacute exposure.Int Arch Occup Environ Health. 2014, 87(6):655-62.
11. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. Biochim Biophys Acta, 2013, 1830: 4848-4859.
12. Zeng T, Zhang CL, Zhao XL, Xie KQ. The roles of garlic on the lipid parameters: a systematic review of the literature. Crit Rev Food Sci Nutr, 2013, 53: 215-230
13. Zeng T, Zhang CL, Han XY, Zhao S, Xie KQ. Association between CD14-159C>T polymorphisms and the risk for alcoholic liver disease: a meta-analysis. Eur J Gastroenterol Hepatol, 2013, 25, 1183-1189.
14. Zeng T, Li Y, Zhang CL, Yu LH, Zhu ZP, Zhao XL, Xie KQ. Garlic oil suppressed the hematological disorders induced by chemotherapy and radiotherapy in tumor-bearing mice. J Food Sci, 2013, 78: H936-942.
15. Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. Roles of Cytochrome P4502E1 Gene Polymorphisms and the Risks of Alcoholic Liver Disease: A Meta-Analysis. PloS one, 2013, 8:e54188.
16. Zhang CL, Zeng T, Zhao XL, Xie KQ. Garlic oil attenuated nitrosodiethylamine-induced hepatocarcinogenesis by modulating the metabolic activation and detoxification enzymes. Int J Biol Sci. 2013, 9(3):237-45.
17. Chen J, Zeng T, Zhao X, Xie K, Bi Y, Zhong Z, Zhao X. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. Food Chem Toxicol. 2013, 57:330-7.
18. Zhong Z, Zeng T, Xie K, Zhang C, Chen J, Bi Y, Zhao X.Elevation of 4-hydroxynonenal and malondialdehyde modified protein levels in cerebral cortex with cognitive dysfunction in rats exposed to 1-bromopropane.Toxicology. 2013, 306:16-23.
19. Zeng T, Zhang CL, Song FY, Zhao XL, Yu LH, Zhu ZP, Xie KQ. PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice. Toxicology, 2012, 296:56-66.
20. Zeng T, Zhang CL, Song FY, Zhao XL, Xie KQ. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-alpha, and CYP2E1. Food Chem Toxicol, 2012, 50:485-491
21. Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, Xie KQ. A meta-analysis of randomized, double-blind, placebo-controlled trials for the effects of garlic on serum lipid profiles. J Sci Food Agric, 2012, 92:1892-1902
22. Song F, Han X, Zeng T, Zhang C, Zou C, Xie K.Changes in beclin-1 and micro-calpain expression in tri-ortho-cresyl phosphate-induced delayed neuropathy.Toxicol Lett. 2012, 210(3):276-84.
23. Zhang CL, Zeng T, Zhao XL, Yu LH, Zhu ZP, Xie KQ. Protective effects of garlic oil on hepatocarcinoma induced by N-nitrosodiethylamine in rats. Int J Biol Sci. 2012, 8 (3):363-74.
24. Xing X, Zeng T, Dou DD, Zhao S, Du JY, Pei JJ, Xie KQ, Zhao XL. Changes of Ultrastructures and Mitochondrial Membrane Permeability in nerve tissue of hens treated with tri-ortho-cresyl phosphate (TOCP). Hum Exp Toxicol. 2011, 30(8): 1062-72.
25. Si J, Wu X, Wan C, Zeng T, Zhang M, Xie K, Li J. Peripubertal exposure to low doses of tributyltin chloride affects the homeostasis of serum T, E2, LH, and body weight of male mice. Environ Toxicol. 2011, 26(3):307-14
26. Zeng T, Xie KQ. The differential modulation on cytochrome P450 enzymes by garlic components. Food Reviews International.2010, 26(4):353-363.
27. Wang Y, Zeng T, Wang SE, Wang W, Wang Q, Yu HX. Fructo-oligosaccharides enhance the mineral absorption and counteract the adverse effects of phytic acid in mice. Nutrition. 2010, 26(3):305-11
28. Zeng T, Xie KQ. Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. Arch Toxicol. 2009, 88:1075-1081.
29. Zeng T, Zhang CL, Song FY, Han XY, Xie KQ. The modulatory effects of garlic oil on hepatic cytochrome P450s in mice. Hum Exp Toxicol. 2009 28(12):777–783.
30. Zhu YJ, Zeng T, Zhu YB, Yu SF, Wang QS, Zhang LP, Guo X, Xie KQ. Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurochem Res. 2008, 33(11):2310-2317
31. Wang P, Zeng T, Zhang CL, Gao XC, Liu Z, Xie KQ, Chi ZF. Lipid peroxidation was involved in the memory impairment of carbon monoxide-induced delayed neuron damage. Neurochem Res. 2009, 34(7):1293-1298.
32. Wang P, Zeng T, Chi ZF. Recovery of cognitive dysfunction in a case of delayed encephalopathy of carbon monoxide poisoning after treatment with donepezil hydrochloride. Neurol India. 2009, 57(4):481-482.
33. Song F, Zhang C, Wang Q, Zeng T, Xie K. Alterations in neurofilaments content and calpains activity of sciatic nerve of carbon disulfide-treated rats. Arch Toxicol. 2009, 83(6):587-94.
34. Zeng T, Guo FF, Zhang CL, Zhao S, Dou DD, Gao XC, Xie KQ. Zeng T, Zhang CL, Zhu ZP, Yu LH, Zhao XL, Xie KQ. Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice. Toxicology. 2008, 252(1-3):86-91.
BOOK CHAPTER
Zeng T and Xie KQ. “Chapter 19: Cytochrome P4502E1 gene polymorphisms and the risks of ethanol-induced health problems in alcoholics”. in: “Molecular Aspects of Alcohol and Nutrition, 1st Edition” edited by VinoodB. Patel; Publisher: Elsevier Science; Nov 11, 2015
PRESENTATIONS AND PROFESSIONAL ACTIVITIES
1. Paper Oral Presentation: "Akt suppression induced by CYP2E1 mediated oxidative stress may be involved in chronic ethanol-induced fatty liver" The 5th Forum of CSOT Young Toxicologists. Shenzhen, China, October 25-28, 2016.
2. Paper Oral Presentation: "Roles of Akt in the pathogenesis of fatty liver diseases" he annual meeting of Shandong preventive medicine association, Jinan, China, November 11-13, 2015.
3. Paper Poster Presentation: "DADS effectively attenuated ethanol-induced injury in normal human LO2 cells and in acute ethanol-intoxicated mice by activating HO-1" The ⅩⅢ International Congress of Toxicology (ICT 2013), Seoul, Korea. June 30-July 4, 2013.
4. Paper Oral Presentation: "Hepatoprotective effects of garlic oil against alcoholic fatty liver and the underlying mechanisms" The 3th Forum of CSOT Young Toxicologists. Shanghai, China, May 11-20, 2011.
5. Paper Oral Presentation: "Garlic oil prevented cute ethanol-induced hepatosteatosis via inhibition of microsomal oxidases and activation of antioxidant system" 1st Congress of Fatty Liver and Metabolic Syndrome (From Basic Science to the Clinical Praxis), Budapest, Hungary. November 12-14, 2009.
